Both the Nautilus and Murano have child safety locks to prevent children from opening the rear doors. The Nautilus has power child safety locks, allowing the driver to activate and deactivate them from the driver's seat and to know when they're engaged. The Murano’s child locks have to be individually engaged at each rear door with a manual switch. The driver can’t know the status of the locks without opening the doors and checking them.
The Nautilus has standard Post Collision Braking, which automatically apply the brakes in the event of a crash to help prevent secondary collisions and prevent further injuries. The Murano doesn’t offer a post collision braking system: in the event of a collision that triggers the airbags, more collisions are possible without the protection of airbags that may have already deployed.
To provide maximum traction and stability on all roads, All-Wheel Drive is standard on the Nautilus. But it costs extra on the Murano.
Both the Nautilus and Murano have rear cross-traffic warning, but the Nautilus has Rear Cross Traffic Braking (automatically applies the brakes) to better prevent a collision when backing near traffic. The Murano’s Rear Cross Traffic Alert doesn’t automatically brake.
Both the Nautilus and the Murano have standard driver and passenger frontal airbags, front side-impact airbags, driver and front passenger knee airbags, side-impact head airbags, front and rear seatbelt pretensioners, height adjustable front shoulder belts, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, daytime running lights, lane departure warning systems, blind spot warning systems, rearview cameras, rear cross-path warning and driver alert monitors.